The development is set to be approved by planners, and will be the latest in a series of hotel developments to come forward in the area.
The proposals by architect Falconer Chester Hall for a building, which will be partly four storeys, and partly eight, linked to four existing listed Georgian houses between 118 and 126 Duke Street.
Planning permission was previously granted for a residential scheme of 151 apartments, but the fresh proposals are being brought forward following interest from a hotel operator, which will take on the site subject to planning consent.
FCH's proposals include a new-build element which sits on the corner of Kent Street and Henry Street; this will link to the grade two-listed terraces which will be refurbished to provide aparthotel units. These are divided between 13 accessible rooms, 47 one-bedroom apartments, and 140 studios. At lower ground and ground floor level, there will be a gym, office, and concierge.
Liverpool City Council's planning committee is due to discuss the proposal at a meeting next week with officers putting forward a recommendation for approval, subject to a legal agreement. Planning officers said: "The hotel proposal will facilitate the viable re-use of valued heritage assets, and also enable the efficient regeneration of a long-term urban brownfield site, and in doing so create a vibrant and inviting local environment."
Close to the scheme, 151-155 Duke Street is currently being converted into an Epic Aparthotel.